Compound Handling to Enable High-Throughput Screening of the EU-OPENSCREEN Compound Collection Across Europe

 In this Case Study, the EU-OPENSCREEN compound storage and management facility in Berlin, Germany, describes how it used a highly integrated automated system to produce over 1.5 million compound aliquots of its Compound Collection for High-Throughput Screening (HTS) studies at its partner sites.

Highlights of this Case Study:

• Description of a highly integrated system consisting of thirteen instruments, including a Hamilton Verso^® Compound Management System and two Hamilton Microlab^® STAR(let) liquid handlers
• Detailed description of the automated methods for compound dissolution and aliquoting, compound (un)loading to/from -20 °C storage, and compound reformatting
• Data exchange among instruments and use of the Hamilton VENUS^® software as the central hub